2,2,2-Trichloroethanimidic acid methyl ester

2,2,2-Trichloroethanimidic acid methyl ester - Names and Identifiers

Name	Methyl 2,2,2-trichloroacetimidate
Synonyms	Methyl trichloroacetimidate Methyl 2,2,2-trichloroacetimidate Methyl 2,2,2-trichloroethanimidate Trichloroacetimidic acid methyl ester methyl (1Z)-2,2,2-trichloroethanimidoate Methyl 2,2,2-trichloroethanecarboxiMidate (2,2,2-trichloro-1-methoxyethylidene)azanide 2,2,2-Trichloroethanimidic acid methyl ester
CAS	2533-69-9
EINECS	219-796-8
InChI	InChI=1/C3H4Cl3NO/c1-8-2(7)3(4,5)6/h7H,1H3/b7-2-
InChIKey	OGBINJLTBZWRRB-UHFFFAOYSA-N

2,2,2-Trichloroethanimidic acid methyl ester - Physico-chemical Properties

Molecular Formula	C3H4Cl3NO
Molar Mass	176.43
Density	1.425 g/mL at 25 °C (lit.)
Melting Point	-30 °C
Boling Point	148-149 °C (lit.)
Flash Point	165°F
Vapor Presure	5.34mmHg at 25°C
Appearance	Liquid
Specific Gravity	1.425
Color	Clear colorless to pale yellow
pKa	2.22±0.70(Predicted)
Storage Condition	2-8°C
Refractive Index	n20/D 1.478(lit.)

2,2,2-Trichloroethanimidic acid methyl ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
HS Code	29252900

2,2,2-Trichloroethanimidic acid methyl ester - Introduction

Methyl 2,2,2-trichloroacetimidate is an organic compound with the chemical formula C4H5Cl3NO. The following is an introduction to some of its properties, uses, methods and safety information:

Nature:
-Appearance: colorless liquid
-Melting point:-41 ℃
-Boiling point: 140 ℃
-Density: 1.602g/cm3
-Solubility: Soluble in various organic solvents

Use:
- Methyl 2,2,2-trichloroacetimidate can be used as a reagent in organic synthesis, mainly used as a catalyst for esterification and acylation reactions.
-It can be used to prepare organic compounds such as heterocyclic compounds, amino acid ester compounds and antibiotics.

Method:
- Methyl 2,2,2-trichloroacetimidate can be prepared by the reaction of 2,2, 2-trichloroacetimine with methanol. The specific preparation steps are as follows:
1. Add 2,2, 2-trichloroacetoximine to the reaction vessel.
2. Gradually add methanol while heating the reaction vessel.
3. After the reaction is completed, the solvent is removed to obtain the product.

Safety Information:
- Methyl 2,2,2-trichloroacetimidate is an organic solvent that is volatile and flammable. Exposure to fire and high temperatures should be avoided.
-It is irritating to the eyes and skin. Avoid direct contact when using it, and wear appropriate protective equipment, such as gloves and goggles.
-Avoid inhaling its vapor and operate in a well-ventilated place.
-When using and storing, please read and follow the relevant safety instructions and precautions.

Last Update：2024-04-10 22:29:15